Cardiovascular disease risk increases if you have autoimmune disorders
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In high -income areas such as Europe and the United States, 10% of the population has been identified as having one or more autoimmune diseases.
Examples include type I diabetes, lupus erythematosus, psoriasis, systemic sclerosis, and rheumatoid arthritis. Although previous studies have suggested the relationship between some of these disorders and the risk of higher cardiovascular disease, this study is often too small and limited to specific autoimmune or cardiovascular conditions to draw strong conclusions about the need to prevent cardiovascular disease among patients with autoimmune diseases.
Before now. An International Research Team led by Ku Leuven presented a comprehensive epidemiological investigation findings of the potential associations between 19 of the most common autoimmune disorders and cardiovascular diseases at the annual Congress of European Cardiology Society, which was held last weekend in Barcelona. According to research findings, individuals with autoimmune diseases are far more likely than healthy people to get cardiovascular disease (between 1.4 and 3.6 times higher risk depending on the autoimmune disease they have). Similar to type 2 diabetes, which is a famous risk factor for cardiovascular disease, this increased risk is comparable to it. This study shows for the first time that autoimmune disease as a set of disorders is influenced by cardiovascular risk rather than individual specific diseases.
The research authors showed that 19 autoimmune diseases they were looking for were about 6% of cardiovascular events. What is important, excess cardiovascular risk is seen in all cardiovascular spectrum, outside of classical coronary heart disease, including heart problems associated with infections, heart inflammation, and thromboembolism and degenerative heart problems, which indicate that the effects of autoimmune diseases in cardiovascular health are health is health Cardiovascular is, showing that autoimmune disease in cardiovascular health is cardiovascular is, indicating that autoimmune diseases in cardiovascular health are cardiovascular, are autoimmune diseases in autoimmune health are cardiovascular is cardiovascular, is an autoimmune disease in autoimmune health. Maybe much broader than what was believed before.
In addition, conventional cardiovascular risk factors such as age, gender, socioeconomic position, blood pressure, BMI, smoking, cholesterol, and type 2 diabetes do not explain increased risk. Another interesting finding is that autoimmune diseases can play an important role in the development of premature cardiovascular disease, which can cause the loss of years and disability of disproportionate life. This excess risk is very high in patients with autoimmune disorders under the age of 55 years.
British Clinical Practice Datalink (CPRD), a collection of patient data that is notified from about one fifth of the country’s current population, functions as a research foundation. The researchers created the new patients’ cohorts were diagnosed with one of 19 autoimmune diseases out of 22 million medical records. They then compared the events of 12 cardiovascular events with suitable control groups, using unmatched granularity levels to be feasible with a very broad size of information.
Patients with one or more autoimmune disorders have an increased risk of cardiovascular disease 1.56 times compared to those who do not have autoimmune diseases. They also found that excessive risk increased with various autoimmune diseases owned by a patient. Conditions with the largest extra risk include type I diabetes, addison, lupus, and systemic sclerosis.
The need for targeted preventive steps
Nathalie Conrad, the main author of this study, said the findings showed the need to take action. We can observe that excessive risk is similar to type 2 diabetes. However, we do not have analog procedures for patients with autoimmune diseases, regardless of the fact that we have special interventions targeted in diabetes patients to minimize the risk of developing cardiovascular disease (in terms of prevention and actions carry on). Conrad refers to the guidelines of European cardiology society about the prevention of cardiovascular disease, which has not yet stated autoimmunity as a cardiovascular risk factor (guidelines only mention some specific disorders, such as lupus) or include specific preventive measures for individuals with autoimmune. disease.
Conrad believes that this research will increase awareness among patients with autoimmune diseases and doctors who treat them, including those in various specialties such as cardiologists, rheumatologists, and general practitioners. “For this patient, we need to set a preventive strategy that is adjusted.” We also need to do additional studies to better understand why people with autoimmune disorders are more likely to get cardiovascular disease than others, and how to stop this happening.
The basic mechanism of pathophysiology is still not fully understood. “The overall theory is that persistent and systemic inflammation, which is a common factor in autoimmune diseases, can cause all types of cardiovascular diseases,” Conrad said. The patient’s cardiovascular risk may also be influenced by the effects of autoimmune diseases on connective tissue, small blood arteries, and cardiomyocytes, and may be some popular treatments for autoimmunity. This really must be seen in depth.
In high -income areas such as Europe and the United States, 10% of the population has been identified as having one or more autoimmune diseases. Examples include type I diabetes, lupus erythematosus, psoriasis, systemic sclerosis, and rheumatoid arthritis. Although previous studies have suggested the relationship between some of these disorders and the risk of higher…