Alzheimer’s disease: Why are women more susceptible? Scientists find answers
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Some epidemiological studies have shown that Alzheimer’s disease (AD) can affect women twice as possible with men even though the exact reason behind this phenomenon is not clear so far. A recent study published in the journal ‘Nature’, might find answers to this question This study, led by Prof. Keqiang Ye from the Shenzhen Advanced Technology Institute (SIAT) of the Chinese Academy of Science, said the C / EBPB / AEP line was the main factor that encouraged the pathogenesis of neurodegenerative diseases “Based on this theory, our team looks for women’s hormones that dramatically change during menopause and test which hormones selectively selectively activate the C / EBPB / AEP path,” said Prof Ye, added that they found hormones that stimulate follicles (FSH) as The main pathogen factor.
“During menopause, serum fsh concentration is greatly increased, binding serum FSH receptors to neurons and activating the C / EBPB / AEP path. This results in pathology ab and know, which leads to AD’s development,” said Dr. Zaidi Mone, Joint Research Author and Terenour Professor On Mount Sinai School of Medicine in New York.
What is Alzheimer’s disease:
In Alzheimer’s disease, someone slowly began to forget everything he knew. In AD, both patients, and caregivers, suffer from causing big problems.
Methods to demonstrate findings:
The researchers said they used ovarianectomy mice to carry out anti-fsh antibody treatments, which blocked FSH and disabled the path of C / EBPB / AEP. After removing the expressions of FSH receptors (FSHR) in neurons to eliminate the binding of FSH to FSHR in the hippocampus, they see it relieves pathology and cognitive dysfunction. They also found that Knockdown of C / EBPB in ad mouse models also reduced advertising pathology They not only worked with female mice but also injected FSH to male mice just to find it promoting advertising pathology.
Findings:
The researchers found an increase in FSH after menopause binding to FSHR in neurons and activating the path of C / EBPB / AEP, which played an important role in triggering advertising pathology. They now plan to dissect the relationship between specific risk genes such as APOE4 and FSH to explore why the female APOE4 carrier is more susceptible to AD.
Some epidemiological studies have shown that Alzheimer’s disease (AD) can affect women twice as possible with men even though the exact reason behind this phenomenon is not clear so far. A recent study published in the journal ‘Nature’, might find answers to this question This study, led by Prof. Keqiang Ye from the Shenzhen Advanced…